Selective Serotonin Reuptake Inhibitors (SSRIs)
In the two studies conducted with Lamotrigine for treating DPD, one concluded that Lamotrigine showed some treatment efficacy (meaning, it worked), while in the other, the same result was NOT observed. Glutamate release is known to cause dissociative symptoms, such as depersonalization and derealization. Neurotransmitters are chemical messengers that transmit signals between nerve cells or neurons. It has been observed that Lamotrigine blocks the release of the neurotransmitter glutamate. Lamotrigine is an anticonvulsant and a mood stabilizer. Currently, no pharmaceutical company is developing a naloxone/naltrexone-based drug exclusively for the treatment of DPD. When consumption of Naloxone or Naltrexone stops, the symptoms and the illness may return. In another study, fourteen subjects were treated with Naltrexone and it was found that there was an average of 30% reduction in symptoms.īoth these studies are promising, but it should also be noted that in both cases, the effect was only temporary.
DEPERSONALIZATION AND DEREALIZATION FREE
In one study conducted, three of the fourteen patients who were administered Naloxone were found to be free of depersonalization symptoms, whereas seven showed marked improvement. That means taking Naltrexone or Naloxone can lead to experiencing less of dissociative states such as depersonalization, derealization, and their various symptoms. It has been hypothesized that blocking opioid receptors in the brain leads to a decline in opiate-modulated dissociative states. You may have heard about Naloxone and Naltrexone in the news being used in case of opioid overdoses, but do you know that they may help with the treatment of depersonalization/derealization as well? Naloxone and Naltrexone are opioid antagonists that have shown some efficacy in treating DPD. Now that we got that out of the way, let’s dive in and see what medications are available for the treatment of depersonalization (DP) and derealization (DR), and their symptoms. In some cases, when the severity of the illness is very strong, there is nothing more helpful than having some relief from the mental agony with the help of a prescription pill. Nonetheless, it is my belief that taking medication for mental illness is fine, as long as one is aware of the above caveats. In my opinion, medication should not be the first resort of a patient dealing with depersonalization, derealization, anxiety, or panic disorder. In most cases, people who come through a difficult illness, such as depersonalization, without the help of medication are LESS afraid when the symptoms return. Medication may also prevent the patient from developing their inner strength, courage, and resilience to go through the motions of an illness. These side effects can range anywhere from mild nausea and upset stomach, to having suicidal thoughts and ideation. One also needs to be aware of the potential side effects of using medication for treating a mental illness. Most of the time, these imbalances can be psychological, resulting from years of abuse, trauma from other sources, or sometimes even spontaneous occurrences ( spiritual emergencies). Most modern-day medications are aimed at reducing the severity of the symptoms and do not treat the underlying imbalance.
Psychopharmacological medication usually doesn’t deal directly with the root cause of mental illness. With that being said, let me reiterate this fact: so far, there has not been any medication developed to specifically treat depersonalization & derealization disorder. Please do your own research and always be sure to consult with a psychiatrist or a medical doctor before consuming any medication. I’m not a medical doctor nor a licensed therapist. In this article, I hope to cover some of the medication available for dealing with DPD and its symptoms. Are there any medications that help heal depersonalization and derealizaiton? Will it help you recover completely or can it help reduce the intensity of DP/DR symptoms?Ī question that I often get asked is, “What are some of the medications that are currently available for treating depersonalization disorder (DPD)?” While I tell my clients that there is no medication available for treating DPD specifically, there are some that may alleviate certain symptoms of the illness.
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